Each tablet contains Cilnidipine 10 mg + Metoprolol 25 mg or 50 mg.

Nulong MT Tablets combine Cilnidipine, a dual L/N-type calcium channel blocker, with Metoprolol, a cardioselective beta1-adrenergic receptor blocker, to provide comprehensive blood pressure control. Cilnidipine produces sustained vasodilation by inhibiting calcium influx into vascular smooth muscle while reducing sympathetic overactivity, whereas Metoprolol lowers heart rate, cardiac output, and myocardial oxygen demand. This complementary combination provides effective once-daily management of hypertension while reducing cardiovascular workload.

Nulong MT Tablets are indicated for the treatment of essential hypertension in adults requiring combination antihypertensive therapy.

Cilnidipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, resulting in peripheral vasodilation and reduction of systemic vascular resistance. It also blocks N-type calcium channels, thereby suppressing sympathetic nerve activity and contributing to effective blood pressure reduction. Metoprolol is a selective β1-adrenergic receptor blocker that lowers blood pressure by reducing heart rate, decreasing myocardial contractility and cardiac output, inhibiting isoproterenol-induced tachycardia, reducing reflex orthostatic tachycardia, and lowering systolic blood pressure during exercise. Together, these agents provide complementary mechanisms for sustained antihypertensive efficacy.

The recommended dosage is one tablet once daily, preferably with food, or as directed by the physician. The dosage should be individualized according to the patient's clinical response and blood pressure control.

Nulong MT Tablets are contraindicated in patients with known hypersensitivity to Cilnidipine, Metoprolol, or any component of the formulation, aortic stenosis, severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, and sick sinus syndrome, unless a permanent pacemaker is in place.